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Given the ubiquity of unstructured biomedical data, significant obstacles still remain in achieving accurate and fast access to online biomedical content. Accompanying semantic annotations with a growing volume biomedical content on the internet is critical to enhancing search engines’ context-aware indexing, improving search speed and retrieval accuracy. We propose a novel methodology for annotation recommendation in the biomedical content authoring environment by introducing the socio-technical approach where users can get recommendations from each other for accurate and high quality semantic annotations. We performed experiments to record the system level performance with and without socio-technical features in three scenarios of different context to evaluate the proposed socio-technical approach. At a system level, we achieved 89.98% precision, 89.61% recall, and an 89.45% F1-score for semantic annotation recollection. Similarly, a high accuracy of 90% is achieved with the socio-technical approach compared to without, which obtains 73% accuracy. However almost equable precision, recall, and F1- score of 90% is gained by scenario-1 and scenario-2, whereas scenario-3 achieved relatively less precision, recall and F1-score of 88%. We conclude that our proposed socio-technical approach produces proficient annotation recommendations that could be helpful for various uses ranging from context-aware indexing to retrieval accuracy.